Samuel and Evans unavailable
The 49ers will be without receivers Deebo Samuel Sr. and Mike Evans in Week 9, while running back Christian McCaffrey and defensive end Nick Bosa are active. Samuel did not practice on November 6 because of a hamstring injury. Evans also missed practice and is listed with rib and Achilles injuries. Both receivers were designated out and appear on the game-day inactive list. Their absences reduce San Francisco’s receiving options and rule both players out for fantasy lineups.
Three questionable players are active
Receiver Demarcus Robinson, safety Siran Neal and cornerback Upton Stout are active after being listed as questionable. All three were limited in practice on November 6. Robinson is dealing with an ankle injury, Neal with knee and foot injuries, and Stout with shoulder and neck injuries. Robinson’s availability gives San Francisco another receiving option with Samuel and Evans unavailable. McCaffrey participated fully despite his hamstring injury, as did Bosa with a knee injury. Safety Marques Sigle also practiced fully with an ankle injury and is active. For fantasy purposes, McCaffrey and Robinson are available, though their active status alone does not establish their workloads.
Other practice and inactive notes
Linebackers Garret Wallow and Luke Gifford practiced fully with hamstring and groin injuries, respectively. Defensive end Mykel Williams was a full participant with a knee injury. Tackle Trent Williams also participated fully; his practice listing was for rest rather than an injury. Joining Samuel and Evans on the inactive list are offensive tackle Enrique Cruz Jr., defensive end Khalid Kareem, quarterback Kurtis Rourke and linebacker Tatum Bethune.
Reserve-list context
Receivers Christian Kirk, Ricky Pearsall and De’Zhaun Stribling are listed on IR, while Brandon Aiyuk carries an Out designation. Kirk also appeared on the practice report as out with a knee injury. Cornerback Nate Hobbs is listed as IR-R, and running back Isaac Guerendo carries a PUP-R designation.