Offensive skill positions
Brock Purdy holds the top quarterback spot on the 49ers’ Week 10 depth chart, with Mac Jones second and Kurtis Rourke third. Christian McCaffrey leads the running backs ahead of Kaelon Black, while Kyle Juszczyk occupies the first fullback slot. Mike Evans sits first at wide receiver, followed by Demarcus Robinson. George Kittle leads a four-player tight end order: Luke Farrell is second, Brayden Willis third and Jake Tonges fourth. For fantasy purposes, McCaffrey, Evans and Kittle hold the leading positions in their respective groups. Black, Robinson and Farrell occupy the next spots behind them; that order establishes their depth-chart standing, not a projected workload.
Offensive line
The first-unit line lists Trent Williams at left tackle, Connor Colby at left guard, Jake Brendel at center, Dominick Puni at right guard and Colton McKivitz at right tackle. Vederian Lowe is second at left tackle, with Austen Pleasants fourth. Nick Zakelj holds the third spot at left guard. Across the other three positions, Jarrett Patterson is Brendel’s second-listed option at center, Carver Willis follows Puni at right guard and Enrique Cruz Jr. follows McKivitz at right tackle.
Defensive front and safeties
Nick Bosa leads the right defensive ends, with Mykel Williams second, Andrew Farmer II third and Mikail Kamara fourth. On the left, Keion White holds the top spot ahead of Romello Height, Khalid Kareem and Sam Okuayinonu, in that order. Osa Odighizuwa leads the left defensive tackles, followed by Sebastian Valdez and C.J. West. DeForest Buckner tops the right defensive tackle group, with James Thompson Jr. second, Alfred Collins third and Gracen Halton fourth. At safety, Ji’Ayir Brown holds the first free safety position, while Darrick Forrest is third. Malik Mustapha leads the strong safeties ahead of Marques Sigle and Siran Neal.
Specialists and return order
Deebo Samuel Sr. holds the first kickoff-return spot, followed by Jordan James in second and Isaac Guerendo in fourth. Jacob Cowing leads the punt-return group, with Jordan Watkins second, Christian Kirk third and Ricky Pearsall fourth. The return assignments give Samuel and Cowing the leading roles in those two groups. Corliss Waitman occupies the first punter slot, and Jon Weeks holds the top long-snapper position.